Transplantation. Jul 27;66(2) Uricosuric effect of the angiotensin II receptor antagonist losartan in heart transplant recipients. Minghelli G(1). This agent promotes uric acid excretion via effects on the organic anion transport The AIIA losartan also produces a uricosuric effect in healthy volunteers. Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act.
|Published (Last):||16 January 2008|
|PDF File Size:||13.80 Mb|
|ePub File Size:||12.79 Mb|
|Price:||Free* [*Free Regsitration Required]|
Uricosuric effect of losartan in patients with renal transplants.
Uricisuric patients provided written informed consent for their participation in the study whose protocol had been authorized by the ethical committee of Tottori University. Clinical and neuropathologic analysis of intracerebral hemorrhage in patients with cerebral amyloid angiopathy.
The ACR Guidelines endorse the use of additional uricosuric agents such as fenofibrate and losartan in combination with xanthine oxidase inhibitors olsartan target urate levels are not met with first-line agents alone [ Khanna et al.
First-line urate-lowering agents are xanthine oxidase inhibitors such as allopurinol and febuxostat. The lack of effect of URAT1 inhibitors on renal excretion of urate was independent of the renal function of hypouricemic patients. Thus, we postulate that losartan induces a particularly brisk response of BP regardless of Sur values.
Uricosuric – Wikipedia
Elevated uric acid uricosjric blood pressure in the rat by a novel crystal-independent mechanism. Comorbidities of gout and hyperuricemia in the US general population: Humans lack the enzyme uricase, which is responsible for breaking down ingested purines from dietary sources e. Arch Intern Med ; Some duplicate citations were included in these results and were removed by comparing each result against the prespecified inclusion and exclusion criteria.
Because changes in renal excretion of urate induced by angiotensin receptor blockers might be influenced by renal adaptation during their administration, we reexamined the acute effects of candesartan before and 2 h after its administration on renal excretion of urate.
From a baseline serum uric acid level of 9.
Discussion This review explored the available literature for the urate-lowering effects of ARBs. This effect of losartan was comparable with the effect of benzbromarone on the renal excretion of urate in hypertensive patients. Two-way analysis of variance with repeated measures was performed to analyze the effects of losartan and candesartan.
The effect of angiotensin II receptor blockers on hyperuricemia
J Am Soc Nephrol ;9: Uricosuric action of losartan via the inhibition of urate transporter 1 URAT 1 in hypertensive patients.
All patients carried the wild-type SLC22A12 gene. A placebo-controlled, forced titration study. Antiuricosuric drugs are useful for treatment of hypouricemia and perhaps also hyperuricosuriabut are contraindicated in persons with conditions including hyperuricemia and gout. However, candesartan did not influence Cur 5. Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia. The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules.
Patients and clearance study in hypertensive patients. Effect of eposartan and losartan on uric acid metabolism in patients with essential hypertension.
Although beyond the scope of this review, other clinically meaningful results unrelated to gout manifestations have been lowartan. Five hypertensive outpatients with idiopathic renal hypouricemia 49 years old on average, three men and four normotensive outpatients with idiopathic renal hypouricemia all women whose average age was 56 were enrolled for this study.
Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. Furthermore, effeect quality of life and gout attack free intervals would help quantify the relevance of incorporating losartan with xanthine oxidase inhibitors for gout management.
This makes it difficult to extrapolate the longer potential effects on serum uric acid with losartan use.
Khan and colleagues conducted a randomized, open-label, prospective, comparative study in which 60 patients with hyperuricemia ranging from 7. Urate transport in the kidney involves glomerular filtration, reabsorption, secretion, and postsecretory reabsorption.
First-line interventions include dietary modifications such as exercise and consuming a low purine diet [ Crittenden and Pillinger, ; Khanna et losartwn.
Changes in lab values such as elevations in serum creatinine and potassium were noted; however, these results were deemed clinically insignificant as they remained within normal limits [ Dang et al. Losartan plus benzbromarone significantly decreased serum uric acid from 4.
There were no significant changes in biochemical parameters such as liver enzymes, serum levels of creatinine, sodium and bicarbonate. Drugs with other primary uses, that have known uricosuric properties, include losartan atorvastatinand fenofibrate.