Triclosan (Irgasan DP ) (List of chemicals that may cause contact dermatitis / Chemicalien die contacteczeem kunnen veroorzaken). Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in . Chemicals, which was acquired in by chemical giant BASF. BASF currently manufactures TCS under the brand name Irgasan DP Irgasan® DP Product Info. Description, Language, Legal Area. Material Safety Data Sheet, EN, CA, View (k). Material Safety Data Sheet, FR, CA, View.
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Under a reflux process, 2,4,4′-trichloro-2′-methoxydiphenyl ether is treated with aluminium chloride. The earliest known safety testing began in Reopening of the Administrative Record.
Additive in plastics, polymers and textiles to give these materials antibacterial properties Anti-microbial creams Anti-odor insoles and hose Bath additives Body wash Commercial laundry products Cosmetics Deodorant soaps Deodorants and antiperspirants Detergents, dish washing liquids Disposable paper products Foot powders and sprays Laundry products Shampoos Toothpaste.
Journal of Hospital Infection.
Disinfection of the skin with detergent preparations of Irgasan DP 300 and other antiseptics.
A study by Colgate-Palmolive found a significant reduction in gingivitis, bleeding, and plaque with the use of triclosan-containing toothpaste,  but an independent review of the Cochrane group suggests that while the reduction in gingivitis, bleeding, and plaque may be iragsan significant, it may not be beneficial enough to yield clinical significance.
Its efficacy as an antimicrobial agentthe risk of antimicrobial resistanceand its possible role in disrupted hormonal development remains controversial. The list states that triclosan is currently allowed in cosmetics up to 0. Retrieved on October 27, Patchen; Itani, Kamal M. Solubility of triclosan in selected solvents and chemicals – Figures and Tables”.
In light of mounting evidence on the human health and ecotoxic effects of triclosan, some companies reformulated to remove it in advance of regulation: It has also been found in land animals including earthworms and species higher up the food chain. While studies using semi-permeable membrane devices have found that triclosan does not strongly bioaccumulate, methyl-triclosan is comparatively more stable and lipophilic and irtasan poses a higher risk of bioaccumulation.
Phenols often demonstrate antibacterial properties. Results from a idgasan published in The American Journal of Infection Control showed that exposure to triclosan was associated with a high risk of developing resistance and cross-resistance in Staphylococcus aureus and Escherichia coli.
Journal of Dermatological Science. Concern pertains to the potential for cross-resistance or irgaszn to other antimicrobials.
IRGASAN DP 300
Irgzsan of Emerging Concern in the Environment. Effective or Just Risky? The United States Pharmacopeia formulary has published a monograph for triclosan that sets purity standards. During wastewater treatment, a portion of triclosan is degraded, while the remaining adsorbs to sewage sludge or exits the plant as effluent.
Retrieved May 3,https: Comparison of different methods of cutaneous sensitization with “weak” allergens. Toxic effects of dioxin contaminations.
Retrieved October 29, Triclosan was developed in the s. Because the FDA prohibited hexachlorophenea irgassan similar to triclosan, Halden and others argued that the FDA should also ban triclosan.
Triclosan (Irgasan DP )
In healthcare, triclosan is used in surgical scrubs and hand washes. The 19 ingredients are: FDA is issuing this notice of proposed rulemaking on topical antimicrobial drug products after considering the public comments on that notice and other information in the administrative record for this rulemaking.
Food and Drug Administration. Retrieved from ” https: A comprehensive analysis in from the University of Michigan School of Public Health indicated that plain soaps are just as effective as consumer-grade antibacterial soaps with triclosan in preventing illness and removing bacteria from the hands. Lay summary — Phys. Ethacridine lactate 9-Aminoacridine Euflavine. Triclosan was used as a hospital scrub in the s. Swiss Contact Dermatitis Research Group. Food Additives and Contaminants.
Triclosan was not approved by the European Commission as an active substance for use in biocidal products for product-type 1 in January The Science of the Total Environment.
Journal of Allergy and Clinical Immunology.
It is highly toxic to various types of algae and has the potential to affect the structure irgaswn algal communities, particularly immediately downstream of effluents from wastewater treatment facilities that treat household wastewaters. Studies on rats have shown that triclosan exposure modulates estrogen-dependent responses.
Production of N-Vinyl Pyrrolidone”. Retrieved October 27,from http: Not to be confused with triclocarban.
Environmental Science and Technology. The use of triclosan-toothpaste may not be associated with any increase in serious adverse cardiac events. It is similar in its uses and mechanism of action to triclocarban. EPA generally regulates uses on solid surfaces, and FDA regulations cover uses in personal care products. Some of these intermediates convert into dioxins upon exposure to UV radiation from the sun or other sources. What Consumers Should Idgasan. As ofthere were five registrations [ further explanation iegasan ] for triclosan with the EPA.