Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.
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Geomatrix: one or two layers oral drug delivery platform technology
Swelling and release mechanism study. It has been shown that generally constant drug release can be achieved when both barrier layers are hydrophilic and the core layer is hydrophobic [ 425 ].
Implantable, polymeric systems for modulated drug delivery. Innovative Drug Delivery Solutions. Upon employing HPMC as a barrier layer, the layer swelled concurrently with the core tablet, merging the core surfaces thereby enveloping part of the core, which resulted in the limiting of drug transport through the barriers [ 40 ].
The tablets were also assessed for goematrix reproducibility. Compressed donut-shaped tablets with zero-order release kinetics. Novel drug delivery devices for providing linear release profiles fabricated by 3DP. Geolock TM Technology Geolock TM Technology is a triple layered tablet that has been devised for chronotherapy focused-real time oral drug delivery [ 85 ]. Zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system.
Royal Bank of Canada.
Kinetic modeling on drug release from controlled drug delivery systems. Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride. Various polymeric formulations of multilayered tablets and possible drug release behavior adapted from Chidambaram et al.
Pharmacokinetic teechnology showed ready absorption in the colon in the fasted state, the tablet remaining intact for almost 17 h. The guar gum acted as a release retardant.
Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery
According to shape of core, zero-order kinetics. Commonly, in bilayered systems, one layer contains a quantity of drug for conferring immediate release, while the second layer contains a quantity of drug for extended release. Table 1 Advantages of multi-layered tablets over conventional tablets Adapted from Namdeo [ 64 ].
The system was comprised of a swellable, asymmetric triple-layered tablet that was also floatable so as to increase the gastric retention time of the system. Danckwerts developed a core-in-cup tablet system that was able to provide zero-order drug release of aqueous-soluble and aqueous-insoluble drugs.
The device is also able to deliver up to two drugs simultaneously with varying release profiles [ 36 ].
The results also indicated that as the size of the hole increased, the geimatrix of drug release also increased. An approach to oral controlled drug delivery via gastric retention. It is a well-established, validated and customisable oral drug delivery platform technology that is currently used in 8 products that are available in over 80 countries. Study showed that the addition of the drug-free layer, its composition and thickness could change the release profile .
The release rate from these formulations enabled a twice daily administration of the delivery system [ 92 ]. The sides of the indentation were not completely coated, which left an aperture where drug release could occur. We believe in nurturing a customer-centric ethos. This type of drug release does not allow for appropriate plasma drug level balance. A flexible technology for the linear, pulsatile and delayed release of drugs allowing for easy accommodation of difficult in vitro targets.
This caused an increase in the diffusion path length for the drug and the drug release rate was therefore reduced. The multi dimensional dynamics of Geomatrix -people, processes, technologies Zerbe and co-workers have shown that there are also complex multilayered tablet systems with layers of various shapes that are able to provide zero-order drug release.
Conclusions It has been elucidated that geometrically altered drug delivery systems, especially multilayered tablets, have provided various advantages to drug delivery technology. HPMC, acacia and tragacanth were used as drug release delaying layers encompassing the core.
A study performed by Chidambaram and co-workers assessed the behavior of layered diffusional matrices for zero-order sustained drug release.
In general, hydro-philic polymers progressively swell on encountering aqueous media thereby increasing gastric residence time, core surface area, and diffusivity for release.
Geomatrix Technology – Oral Drug Delivery – Doctor Steve Abel
Further research that focuses on the use of novel specialized polymers that are competent in providing tschnology drug release is necessary. Network Engineering technllogy Administration.
Assemblage of novel release modules for the development of adaptable drug delivery systems. Geomatrix technology is a new drug delivery device in the form of a multi-layer tablet proposed for constant drug release and was developed at University of Pavia, Italy.
Author information Article notes Copyright and License information Disclaimer. Press coating is a good technique for producing this type of time-dependent release. In the past, polymers that were mainly employed for such purposes were the hydropolymers [ 40 ], while currently polymers investigated range from swollen and non-swollen [ 4051 tecynology, porous and non-porous [ 52 — 54 ] to erodible or non-erodible polymers [ 555 ].
In vitro studies exhibited a sustained delivery of the two drugs over 6—8 hours, while the tablet was retained, showing the potential to achieve localized treatment, thereby improving therapeutic efficacy.