ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Ertapenem is suggested as an option for moderate to severe diabetic wound infections. Guidelines recommend ertapenem for 4 to 7 days for mild-to-moderate community-acquired infections, including perforated or abscessed appendicitis. Other dosage adjustment guidelines for adults: Accumulation does not occur following multiple IM doses in healthy adults.

Complete the infusion within 6 hours of reconstitution. Immediately withdraw the appropriate dose and inject deeply into a large muscle i. For surgical infection prophylaxis for elective colorectal surgery. If ertapenem is given 6 hours or more prior to hemodialysis, no supplemental dosing is required.

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For the treatment of acute pelvic infections, including postpartum endomyometritis, septic abortion, and postsurgical gynecologic infections.

Valproic Acid, Divalproex Sodium: The diluted solution may be refrigerated for up to 24 hours 5 degrees C and used within 4 pcakage after removal from refrigeration.

Case studies have reported ertapenem causing decreases in valproic acid and divalproex serum concentrations when ertapenem was added to their regimen; discontinuation of ertapenem resulted in increased valproic acid concentrations. IM use is contraindicated in patients with an amide local anesthetic hypersensitivity.

Ertwpenem elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Infuse IV over 30 inserrt.

According to OBRA, use of antibiotics should be limited to confirmed or suspected bacterial infections. Products inhibiting peristalsis are contraindicated in this clinical situation.

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In animal studies evaluating doses 1. Almost all antibacterial agents have been associated with pseudomembranous colitis antibiotic-associated colitis which may range in severity from mild to life-threatening.

Lnsert and efficacy have not been established.

Inhibition of vitamin K synthesis due to alterations in the intestinal flora may be a mechanism; however, concurrent infection is also a potential risk factor for elevated INR. For less than 1 g dose: Use within 6 hours if stored at room temperature 25 degrees C.

Prescribing ertapenem in the absence of a proven or strongly suspected bacterial infection or for a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. It is eliminated via the kidney with a prolonged half-life of roughly 4.

Ertapenem Sodium Injection – Par Sterile Products – Products

In setting of a cat or dog bite, preemptive antimicrobial therapy is recommended for 3 to 5 days for patients who are immunocompromised, asplenic, have advanced liver disease, have edema of the bite area, have moderate to severe injuries, particularly of the hand or face, or have penetrating injuries to the periosteum or joint capsule.

May consider IM administration as an alternative to IV administration in the treatment of infections where IM therapy is appropriate; however, only administer inserr IM injection for 7 days.

By day 5 after discontinuation, the concentration in breast milk was undetectable. Anticonvulsive therapy should be continued in patients with a known seizure disorder. Available data from a small number of postmarketing cases with ertapenem use in pregnancy are insufficient to inform any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes.

Invanz (ertapenem) dose, indications, adverse effects, interactions from

Do not co-infuse with other medications. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries e.

Your email has been sent. Ertapenem should be prescribed with caution to patients with inflammatory bowel disease such as ulcerative colitis or other GI disease. Dilute the appropriate volume of the reconstituted solution based ppackage body weight in 0. Ertapenem is known to be substantially excreted by the ertalenem, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.

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Consideration should be given to the diagnosis of pseudomembranous colitis in patients presenting with diarrhea following antibacterial administration. Ertapenem ertapeenm stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.

Ertapenem solution is colorless to pale yellow; variations of color within this range do not affect the potency of the product. Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce efficacy of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria.

Minor Probenecid inhibits the renal excretion of ertapenem by competing with them inzert active tubular secretion.

Ertapenem for Injection

PBP-1 is responsible for formation of the cell wall; PBP-2 is responsible for maintaining the rod-like shape; and PBP-3 is responsible for bacterial septum formation. The IM reconstituted formulation is not for IV use. However, the elimination half-life of ertapenem is increased only from 4 to 4. Dilute the entire contents of the reconstituted vial in 50 mL packagd 0.

During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. IV or IM broad-spectrum carbapenem antibiotic stable against beta-lactamases Used to treat UTI, skin, pelvic, intraabdominal infections and community-acquired pneumonia; used for colorectal surgical prophylaxis Once-daily dosing may be advantageous, but no P.