Management of Benzodiazepine Withdrawal – WS DASSA August Benzodiazepine equivalents. Name. Duration of. Action #. Approx dose. Alprazolam. Xanax. Y**. B. Chlordiazepoxide Librium. Y**. B,E. Clonazepam. Klonopin. – N**. A,B,D,E. Diazepam. Valium. This Benzodiazepine Equivalence Table is based on the extensive research and clinical experience of Professor C Heather Ashton, DM, FRCP.

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Page Contents Page Contents The following guiding principles govern the calculator’s logic:. Handbook of Psychiatric Drugs. Search other sites for ‘Benzodiazepine Equivalents’. Patients should address specific medical concerns with their physicians.

Benzodiazepine Equivalents

Indications Benzodiazepine Withdrawal Barbiturate withdrawal Sedative withdrawal. How they work and how to withdraw; The Ashton Manual. A Comprehensive Study Guide.

Effect of age, gender, and obesity on midazolam kinetics. Benzodiazepine Equivalents Conversion Benzoxiazepine. Management of withdrawal syndromes and relapse prevention in drug and alcohol dependence. Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects.

A psychometric study based on flicker sensitivity, reaction time and digit symbol substitution test. We’ve filled out some of the form to show you this clinical calculator in action. Barbiturate Abuse Benzodiazepine Abuse. Phenobarbital pharmacokinetics and bioavailability in adults.


Lieberman JA, Tasman A. Can J Hosp Pharm. For more information, please view the website disclaimer. The following bioavailabilities are available based on published literature.

Accessed December 31, Related links to external sites from Bing. Miscellaneous Sedative Equivalents References Extra: Related Topics in Chemical Dependency.

This calculator is not a substitute for clinical experience and must be used in conjunction with reasonable clinical judgment. Dose equivalence of midazolam and triazolam. Miscellaneous Sedative Equivalents Glycerol: Br J Clin Pharmacol.

Equivalent Benzodiazepine Calculator

Midazolam, lorazepam, diazepam, and phenobarbital are available in both parenteral and oral formulations. This conversion tool estimates a reasonable equipotent dose between two benzodiazepines.

Started inthis collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters. This calculator only accounts for differences in bioavailability with midazolam. Content is updated monthly with benzodiiazepine literature reviews and conferences.

Benzodiazepines have a narrow equkvalency window – dose adjustments should be made by an experienced clinician.

Due to discrepancies in the benzodiazepne, many benzodiazepine conversions may have a potential conversion range that is extremely variable eg, by a factor of 10x or greater. Unlike nearly all other benzodiazepine conversions, the conversion between intravenous midazolam and lorazepam has been well studied in mechanically ventilated patients. In addition to an overall lack of evidence to support specific conversions, there are a number of other limitations that should be recognized:.

These images are a random sampling from a Bing search on the term “Benzodiazepine Equivalents. Evaluation of an alcohol withdrawal protocol and a preprinted order set at a tertiary care hospital. A double-blind, randomized comparison of i. Benzodiazepines Equivalents Alprazolam Xanax Alprazolam 0. Updated June 3, Home Eqyivalency Blog About.


The Ashton Manual Online. References Ashton Curr Opin Psychiatry Related Bing Images Benzodiazepime Most benzodiazepines included in this calculator are only available as oral dosage forms.

SPS – Specialist Pharmacy Service – The first stop for professional medicines advice

Mental Health – Chemical Dependency Pages. Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.

It should be noted, however, that this conversion is based on chronic administration of continuous intravenous lorazepam or midazolam. While barbiturates do share similar pharmacology to benzodiazepines, they have a more concerning safety profile with a higher incidence of respiratory depression.

Because published benzodiazepine dose conversions are based on oral administration, parenteral formulations may not use the same conversion ratio. Click here to start from scratch and enter your own patient data. In fact, most benzodiazepine equivalence estimates are based on expert opinion, uncited tables in published documents, and clinical practice.